منابع مشابه
Metabolism of chemical carcinogens.
The transformation of chemicals is important in carcinogenesis, both in bioactivation and detoxification. Major advances in the past 20 years include appreciation of the migration of reactive electrophiles, the ability of Phase II conjugating enzymes to activate chemicals, understanding of the human enzymes, the realization that DNA modification can result from endogenous chemicals, and the dem...
متن کاملEffects of dietary constituents on the metabolism of chemical carcinogens.
Dietary constituents of 2 types have been shown to affect the metabolism of chemical carcinogens by the microsomal mixed-function oxidase system. Naturally occurring inducers of increased activity of this system are present in plants. Cruciferous vegetables including Brussels sprouts, cabbage, and cauliflower are relatively potent in this regard. From these vegetables, three indoles with induci...
متن کاملDNA adducts of chemical carcinogens.
Introduction During the 30 years or so following the identification of the first pure chemical carcinogen (1), no common factors or pathways in the mechanism of action of carcinogens from different chemical classes were evident. For this reason perhaps, each class of carcinogen, e.g. the polycyclic aromatic hydrocarbons, the aromatic amines and the nitrosamines, was often reviewed and discussed...
متن کاملChemical Carcinogens and Respiratory Epithelium
In an earlier communication [1], carcinogenic hydrocarbons benzo(a)pyrene (BaP), 7,12-dimethylbenz(a)anthracene (DMBA) and 3-methylcholanthrene (MC) were shown to produce metaplasia and increased proliferation of the epithelium of suckling rat tracheas maintained in organ culture. Tissues exposed for several days by including hydrocarbon in the medium, and tissues so treated and then withdrawn ...
متن کاملPeroxidase-catalysed metabolism of drugs and carcinogens.
Fig. 3. Effect of inhibition of harmol sulphation by 2,6dichloro-4-nitrophenol ( D C N P ) on the excretion of harmol glucuronide (hg) and harmol sulphate (hs ) Harmol was infused at a rate of 0.76pmol/min after an intravenous loading dose of 4.8pmol. Bile and urine were collected as indicated by the mid-point of each collection period, and in each fraction harmol glucuronide and harmol sulphat...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2000
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/21.3.345